Eukaryotic Post-transcriptional Gene Regulation

Review Questions

Which of the following are involved in post-transcriptional control?

  1. control of RNA splicing
  2. control of RNA shuttling
  3. control of RNA stability
  4. all of the above

Hint:

D

Binding of an RNA binding protein will ________ the stability of the RNA molecule.

  1. increase
  2. decrease
  3. neither increase nor decrease
  4. either increase or decrease

Hint:

D

An unprocessed pre-mRNA has the following structure.

Which of the following is not a possible size (in bp) of the mature mRNA?

  1. 205bp
  2. 180bp
  3. 150bp
  4. 100bp

Hint:

A

Alternative splicing has been estimated to occur in more than 95% of multi-exon genes. Which of the following is not an evolutionary advantage of alternative splicing?

  1. Alternative splicing increases diversity without increasing genome size.
  2. Different gene isoforms can be expressed in different tissues.
  3. Alternative splicing creates shorter mRNA transcripts.
  4. Different gene isoforms can be expressed during different stages of development.

Hint:

C