Eukaryotic Translational and Post-translational Gene Regulation

Review Questions

Post-translational modifications of proteins can affect which of the following?

  1. protein function
  2. transcriptional regulation
  3. chromatin modification
  4. all of the above



A scientist mutates eIF-2 to eliminate its GTP hydrolysis capability. How would this mutated form of eIF-2 alter translation?

  1. Initiation factors would not be able to bind to mRNA.
  2. The large ribosomal subunit would not be able to interact with mRNA transcripts.
  3. tRNAi-Met would not scan mRNA transcripts for the start codon.
  4. eIF-2 would not be able to interact with the small ribosomal subunit.